Differential Effects of PDE4 Inhibitors on Cortical Neurons and T-Lymphocytes

• Main Authors: Ryo Hirose (Author), Haruhiko Manabe (Author), Koji Yanagawa (Author), Etsuo Ohshima (Author), Michio Ichimura (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibitors of PDE4 (cAMP-specific phosphodiesterase) induce side effects, including nausea and emesis, that limit their therapeutic potential. We investigated the function of two catalytically active conformations of PDE4 (a low-affinity conformer detected by conventional cAMP hydrolytic activity an...