Effects of <i>Origanum vulgare</i> and <i>Scutellaria baicalensis</i> on the Physiological Activity and Biochemical Parameters of the Blood in Rats on a High-Fat Diet
The pharmacological effects of medicinal plants play a primary role in the mild correction of body weight in humans and animals, reducing the accumulation of fat in their bodies during a state of obesity. <i>Origanum vulgare</i> L. and <i>Scutellaria baicalensis</i> Georgi ar...
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MDPI AG,
2022-08-01T00:00:00Z.
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| Summary: | The pharmacological effects of medicinal plants play a primary role in the mild correction of body weight in humans and animals, reducing the accumulation of fat in their bodies during a state of obesity. <i>Origanum vulgare</i> L. and <i>Scutellaria baicalensis</i> Georgi are widely used as food additives and medicinal plants, but their comprehensive physiological evaluation in model animals in a state of obesity has not been carried out. In a 30-day laboratory experiment on male rats which had developed obesity through a hypercaloric diet, the effects of adding the dry crushed grass <i>O. vulgare</i> or dry crushed roots of <i>S. baicalensis</i> to their feed was evaluated. During the experiment, the rats fed with <i>O. vulgare</i> increased in body weight to only 105.5% of their initial weight, while the body weight of the control group increased to 111.5%, and that of animals fed on <i>S. baicalensis</i> increased to 124.0% of their initial body weight. The average daily increase in the rats' body weight when <i>O. vulgare</i> was added to their diet decreased to 205 mg/day, and when <i>S. baicalensis</i> was added, on the contrary, it increased to 1417 mg/day, compared to 700 mg/day among the control group. Under the influence of <i>O. vulgare</i>, the lipid metabolism of the rats normalized: the atherogenic index decreased to 33.7%, compared with the values of the control group, due to an increase in the concentration of high-density lipoproteins from cholesterol. The concentration of triglycerides decreased, and the concentration of glucose decreased. The roots of <i>S. baicalensis</i> being added into the diet of rats increased the activity of alkaline phosphatase and decreased the concentration of urea. The atherogenic index also decreased (by up to 35.5% in the control group) and the concentration of high-density lipoprotein cholesterol increased, while the concentrations of triglycerides and glucose decreased. The physical activity of the rats showed a slight tendency to decrease when both <i>O. vulgare</i> and <i>S. baicalensis</i> were added to their diet. Both plant species contributed to a decrease in the emotional status of animals, which was most pronounced when the <i>O. vulgare</i> grass was added to the feed. The results of the study demonstrate the potential of the use of <i>O. vulgare</i> and <i>S. baicalensis</i> as herbal supplementations for the correction of hyperlipidemia and type-2 diabetes mellitus in overweight patients. |
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| Item Description: | 10.3390/scipharm90030049 2218-0532 0036-8709 |