Cover Image

A Selective Histamine H4 Receptor Antagonist, JNJ7777120, Is Protective in a Rat Model of Transient Cerebral Ischemia

Cerebral ischemia is a multifactorial pathology characterized by different events evolving in time. The acute injury, characterized by excitoxicity, is followed by a secondary brain injury that develops from hours to days after ischemia. Extracellular levels of histamine increase in the ischemic are...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ilaria Dettori (Author), Lisa Gaviano (Author), Alessia Melani (Author), Laura Lucarini (Author), Mariaconcetta Durante (Author), Emanuela Masini (Author), Felicita Pedata (Author)
Format:	Book
Published:	Frontiers Media S.A., 2018-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Protective Effect of Adenosine A2B Receptor Agonist, BAY60-6583, Against Transient Focal Brain Ischemia in Rat
by: Ilaria Dettori, et al.
Published: (2021)

Adenosine A2A Receptors Modulate Acute Injury and Neuroinflammation in Brain Ischemia
by: Felicita Pedata, et al.
Published: (2014)

Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice
by: Mariaconcetta Durante, et al.
Published: (2019)

Effects of Olopatadine Hydrochloride, a Histamine H𝟏 Receptor Antagonist, on Histamine-Induced Skin Responses
by: Takashi Hashimoto, et al.
Published: (2010)

The Selective Antagonism of Adenosine A2B Receptors Reduces the Synaptic Failure and Neuronal Death Induced by Oxygen and Glucose Deprivation in Rat CA1 Hippocampus in Vitro
by: Irene Fusco, et al.
Published: (2018)

Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
by: Pascal Bonaventure, et al.
Published: (2017)

New Insight into the Role of Adenosine in Demyelination, Stroke and Neuropathic Pain
by: Elisabetta Coppi, et al.
Published: (2021)

Targeted therapy with histamine antagonists - New challenges to fight with breast cancer
by: Piotr Jan Więsyk, et al.
Published: (2022)

Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists
by: Sadek B, et al.
Published: (2016)

Optimization of Transient Focal Cerebral Ischemia Model by Middle Cerebral Artery Occlusion
by: Bahman Jalali Kondori, et al.
Published: (2017)

Translational Model‐Informed Dose Selection for a Human Positron Emission Tomography Imaging Study of JNJ‐54175446, a P2X7 Receptor Antagonist
by: Yan Xu, et al.
Published: (2020)

Cetirizine a histamine H1 receptor antagonist improves viral myocarditis
by: Yamamoto Kanjo, et al.
Published: (2010)

Protective effects of carbonic anhydrase inhibition in brain ischaemia in vitro and in vivo models
by: Ilaria Dettori, et al.
Published: (2021)

Histamine H3 Receptor Antagonist Enhances Neurogenesis and Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments
by: Na Wang, et al.
Published: (2020)

The Histamine H2-Receptor Antagonist, Cimetidine, Inhibits the Articular Osteopenia in Rats With Adjuvant-Induced Arthritis by Suppressing the Osteoclast Differentiation Induced by Histamine
by: Katsunori Yamaura, et al.
Published: (2003)

Possible Role of Nitric Oxide in Anxiety Following Transient Cerebral Ischemia in Mice
by: Mihoko N. Nakashima, et al.
Published: (2003)

Improved Chemical and Radiochemical Synthesis of Neuropeptide Y Y<sub>2</sub> Receptor Antagonist <i>N</i>-Methyl-JNJ-31020028 and Preclinical Positron Emission Tomography Studies
by: Inês C. F. Fonseca, et al.
Published: (2024)

Role of Substance P on Histamine H3 Antagonist-Induced Scratching Behavior in Mice
by: Maria Alejandra Hossen, et al.
Published: (2006)

Antagonistic effect of mepyramine and tubocurarine on the histamine-mediated contraction of intestinal smooth muscle cells
by: Andreé Salvatierra
Published: (2023)

Effects of histamine and its antagonists on murine T-cells and bone marrow-derived dendritic cells
by: Hu XF, et al.
Published: (2015)

Molecular Determinants Responsible for Sedative and Non-sedative Properties of Histamine H1-Receptor Antagonists
by: Yoshihiro Uesawa, et al.
Published: (2014)

QSAR and Molecular Docking Studies on Non-Imidazole-Based Histamine H3 Receptor Antagonists
by: Maryam Hamzeh-Mivehroud, et al.
Published: (2020)

Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1G93A female mice
by: Cristina Ruiz-Ruiz, et al.
Published: (2020)

Inhibition of Autophagy Contributes to Melatonin-Mediated Neuroprotection Against Transient Focal Cerebral Ischemia in Rats
by: Yongqiu Zheng, et al.
Published: (2014)

Protective effect of Kombucha tea on brain damage induced by transient cerebral ischemia and reperfusion in rat
by: Najmeh Kabiri, et al.
Published: (2016)

Effect of obesity on early blood-brain barrier disruption following transient focal cerebral ischemia
by: C. Li, et al.
Published: (2016)

Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia
by: Mark B. Plotnikov, et al.
Published: (2023)

Efficacy of histamine H1 receptor antagonists azelastine and fexofenadine against cutaneous Leishmania major infection.
by: Alex G Peniche, et al.
Published: (2020)

Increased Sensitivity of Mice Lacking Extrasynaptic δ-Containing GABAA Receptors to Histamine Receptor 3 Antagonists
by: Shamsiiat Abdurakhmanova, et al.
Published: (2020)

Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats
by: Folwarczna J, et al.
Published: (2019)

Effect of Mediterranean Diet Enriched in High Quality Extra Virgin Olive Oil on Oxidative Stress, Inflammation and Gut Microbiota in Obese and Normal Weight Adult Subjects
by: Maria Luisa Eliana Luisi, et al.
Published: (2019)

Activation of carbonic anhydrase isoforms involved in modulation of emotional memory and cognitive disorders with histamine agonists, antagonists and derivatives
by: Gustavo Provensi, et al.
Published: (2021)

Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice
by: Bastaki SM, et al.
Published: (2018)

Minocycline Ameliorates Depressive-Like Behavior and Demyelination Induced by Transient Global Cerebral Ischemia by Inhibiting Microglial Activation
by: Bingying Du, et al.
Published: (2019)

Anxiolytic and antidepressant-like activities of the novel and potent non-imidazole histamine H3 receptor antagonist ST-1283
by: Bahi A, et al.
Published: (2014)

Anti-seizure effects of JNJ-54175446 in the intra-amygdala kainic acid model of drug-resistant temporal lobe epilepsy in mice
by: Omar Mamad, et al.
Published: (2024)

Recent Advances in Molecular Pharmacology of the Histamine Systems: Organic Cation Transporters as a Histamine Transporter and Histamine Metabolism
by: Ogasawara Masahito, et al.
Published: (2006)

Histamine in the Brain
by: Maria Beatrice Passani
Published: (2015)

Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety
by: Mingxia Song, et al.
Published: (2020)

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
by: Sadek B, et al.
Published: (2016)