Clathrate Hydrates of Organic Solvents as Auxiliary Intermediates in Pharmaceutical Research and Development: Improving Dissolution Behaviour of a New Anti-Tuberculosis Drug, Perchlozon

• Main Authors: Andrey G. Ogienko (Author), Svetlana A. Myz (Author), Andrey A. Nefedov (Author), Anna A. Ogienko (Author), Tatyana P. Adamova (Author), Olga M. Voronkova (Author), Svetlana V. Amosova (Author), Boris A. Trofimov (Author), Vladimir V. Boldyrev (Author), Elena V. Boldyreva (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is an urgent need for new drugs to overcome the challenge of the ever-growing drug resistance towards tuberculosis. A new, highly efficient anti-tuberculosis drug, Perchlozone (thioureidoiminomethylpyridinium perchlorate, Pz), is only available in an oral dosage form, though injectable forms a...