Сardioprotective agents with biaromatic structure. Part 2. HCN channel blockers
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, primarily their HCN4 subtype, are one of the promising targets for the development of cardioprotective agents. HCN channel blockers have a selective bradycardic effect, preserving myocardial contractility and diastolic function and...
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| Format: | Book |
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LLC "Publisher OKI",
2022-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, primarily their HCN4 subtype, are one of the promising targets for the development of cardioprotective agents. HCN channel blockers have a selective bradycardic effect, preserving myocardial contractility and diastolic function and not affecting the electrophysiological parameters of the heart. This review continues a series of reviews on the analysis of compounds with cardioprotective properties in a number of biaromatic structures, which include a wide range of HCN channel blockers. |
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| Item Description: | 2587-7836 2686-8830 10.37489/2587-7836-2022-2-03-10 |