Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion

• Main Authors: Rita Manguinhas (Author), Ana S. Fernandes (Author), João G. Costa (Author), Nuno Saraiva (Author), Sérgio P. Camões (Author), Nuno Gil (Author), Rafael Rosell (Author), Matilde Castro (Author), Joana P. Miranda (Author), Nuno G. Oliveira (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elevated expression levels of the apurinic/apyrimidinic endonuclease 1 (APE1) have been correlated with the more aggressive phenotypes and poor prognosis of non-small cell lung cancer (NSCLC). This study aimed to assess the impact of the inhibition of the redox function of APE1 with E3330 either alo...