Cerebrospinal fluid penetration of very high-dose meropenem: a case report

• Glavni autori: Thomas Kerz (Autor), Friederike D. von Loewenich (Autor), Jason Roberts (Autor), Axel Neulen (Autor), Florian Ringel (Autor)
• Format: Knjiga
• Izdano: BMC, 2018-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background Standard dosing of meropenem (2 g t.i.d.) produces CSF concentrations of only 1-2 mg/L which is inferior to the clinical breakpoint for most Gram-negative bacteria. There is therefore concern that dosing must be increased in order to achieve therapeutic CSF concentrations for bac...