CpG immunostimulatory oligodeoxynucleotide 1826 as a novel nasal ODN adjuvant enhanced the protective efficacy of the periodontitis gene vaccine in a periodontitis model in SD rats

• Autori principali: Guohui Bai (Autore), Hang Yu (Autore), Xiaoyan Guan (Autore), Fengjiao Zeng (Autore), Xia Liu (Autore), Bin Chen (Autore), Jianguo Liu (Autore), Yuan Tian (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2021-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background We previously demonstrated that nasal administration of periodontitis gene vaccine (pVAX1-HA2-fimA) or pVAX1-HA2-fimA plus IL-15 as adjuvant provoked protective immunity in the periodontal tissue of SD rats. This study evaluated the immune effect of pVAX1-HA2-fimA plus CpG-ODN 18...