Role of the potassium channels in vasorelaxant effect of asafoetida essential oil

• मुख्य लेखकों: Hassan Esmaeili (लेखक), Mansour Esmailidehaj (लेखक), Somayeh Entezari Zarch (लेखक), Hossein Azizian (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Mashhad University of Medical Sciences, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

सारांश

<strong>Objective:</strong> In a previous work, we showed that asafoetida essential oil (AEO), from oleo-gum resin of <em>Ferula asafoetida </em>L. from the Apiaceae family, has a vasodilatory effect. This effect was both endothelium-dependent and endothelium-independent. The present study was designed to determine whether potassium channels and intracellular calcium release contribute to AEO-induced vasodilation.<br /> <strong>Materials and Methods:</strong> Rats' thoracic aorta were isolated and denuded. Following induction of contraction by potassium chloride (60 mM), concentration-response curve was plotted by the cumulative addition of AEO (0.625-80 µl/l to the medium of rings. The vasodilatory effect of AEO was assessed before and after addition of phenylephrine and potassium channel blockers (including barium chloride (BC), 4-aminopyridine (4A) and glibenclamide (Gl)).<br /> <strong>Results:</strong> AEO relaxed the precontracted rings in a concentration-dependent manner (IC50=23 µl/l). All potassium channel blockers significantly attenuated the vasodilatory activity of AEO when they were added to rings medium before addition of KCl (p<0.01, 4A and Gl groups and p< 0.001, BC group vs. control group) but not after that. In contrast to K channel blockers, adding AEO before or after phenylephrine, the tension was reduced significantly (p <strong>Conclusion:</strong> The findings of this study indicated that the vasodilatory effect of AEO on denuded-endothelium aortic ring was mediated through activation of potassium channels and reduced intracellular calcium release.

वस्तु वर्णन

2228-7930
2228-7949
10.22038/ajp.2020.41755.2401