Safety of nurse-directed triage intranasal fentanyl protocol for acute pain management in a European pediatric emergency department: A retrospective observational analysis

BackgroundNurse-directed pain protocols for intranasal fentanyl administration are not widely implemented in European (EU) pediatric emergency departments (PED). Barriers include perceived safety concerns for intranasal (IN) fentanyl. The aim of this study is to describe our experience with a nurse-...

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Glavni autori: F. Romano (Autor), M. Wendelspiess (Autor), R. Mansour (Autor), O. Abplanalp-Marti (Autor), C. Starvaggi (Autor), F. Holzner (Autor), I. Steiner (Autor), K. Keitel (Autor)
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Izdano: Frontiers Media S.A., 2023-02-01T00:00:00Z.
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100 1 0 |a F. Romano  |e author 
700 1 0 |a M. Wendelspiess  |e author 
700 1 0 |a R. Mansour  |e author 
700 1 0 |a O. Abplanalp-Marti  |e author 
700 1 0 |a C. Starvaggi  |e author 
700 1 0 |a F. Holzner  |e author 
700 1 0 |a I. Steiner  |e author 
700 1 0 |a K. Keitel  |e author 
245 0 0 |a Safety of nurse-directed triage intranasal fentanyl protocol for acute pain management in a European pediatric emergency department: A retrospective observational analysis 
260 |b Frontiers Media S.A.,   |c 2023-02-01T00:00:00Z. 
500 |a 2296-2360 
500 |a 10.3389/fped.2023.1070685 
520 |a BackgroundNurse-directed pain protocols for intranasal fentanyl administration are not widely implemented in European (EU) pediatric emergency departments (PED). Barriers include perceived safety concerns for intranasal (IN) fentanyl. The aim of this study is to describe our experience with a nurse-directed triage IN fentanyl protocol with a focus on safety in a tertiary EU PED.MethodsWe conducted a retrospective analysis of patient records of children aged 0-16 years who received nurse-directed IN fentanyl between January 2019 and December 2021 at the PED of the University Children's Hospital of Bern, Switzerland. Extracted data points included demographics, presenting complaint, pain score, IN fentanyl dosage, concomitant pain medication use, and adverse events.ResultsA total of 314 patients were identified with ages ranging from 9 months to 15 years. The main indication for nurse-directed fentanyl administration was musculoskeletal pain due to trauma (n = 284, 90%). Mild adverse events (vertigo) were reported in two patients (0.6%), without a correlation to concomitant pain medication or protocol violation. The only reported severe adverse event of syncope and hypoxia in a 14-year-old adolescent occurred in a setting where the institutional nurse-directed protocol was violated.ConclusionIn accordance with previous studies outside of Europe, our data support the case that when appropriately used, nurse-directed IN fentanyl is a safe potent opioid analgesic for pediatric acute pain management. We strongly encourage the introduction of nurse-directed triage fentanyl protocols Europe-wide in order to provide effective and adequate acute pain management in children. 
546 |a EN 
690 |a pediatric emergency medicine 
690 |a analgesia 
690 |a pain management 
690 |a nurse-directed triage protocol 
690 |a intranasal fentanyl 
690 |a safety 
690 |a Pediatrics 
690 |a RJ1-570 
655 7 |a article  |2 local 
786 0 |n Frontiers in Pediatrics, Vol 11 (2023) 
787 0 |n https://www.frontiersin.org/articles/10.3389/fped.2023.1070685/full 
787 0 |n https://doaj.org/toc/2296-2360 
856 4 1 |u https://doaj.org/article/47a70c61c00d40d09fc8fa49905f46b1  |z Connect to this object online.