Deletion of the NSm virulence gene of Rift Valley fever virus inhibits virus replication in and dissemination from the midgut of Aedes aegypti mosquitoes.

• Main Authors: Rebekah C Kading (Author), Mary B Crabtree (Author), Brian H Bird (Author), Stuart T Nichol (Author), Bobbie Rae Erickson (Author), Kalanthe Horiuchi (Author), Brad J Biggerstaff (Author), Barry R Miller (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Previously, we investigated the role of the Rift Valley fever virus (RVFV) virulence genes NSs and NSm in mosquitoes and demonstrated that deletion of NSm significantly reduced the infection, dissemination, and transmission rates of RVFV in Aedes aegypti mosquitoes. The specific aim of t...