Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323-1 and 323-2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target stability (DARTS), and fluorescence polarization (FP) assays altogether determined...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2022-05-01T00:00:00Z.
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