Hypoxia-Inducible Factor 1-Related Diseases and Prospective Therapeutic Tools
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions. Based on information as to which type...
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| Main Authors: | , , |
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| Format: | Book |
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Elsevier,
2004-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions. Based on information as to which types of genes are controlled by HIF-1, it appears that HIF-1 provides pathological tissues with survival in hypoxic regions or angiogenic activity. Therefore, HIF-1 inhibitors could be useful as therapeutic agents for various diseases associated with the over-activation of HIF-1, such as cancers, cardiovascular remodeling, preeclamsia, and other angiogenesis-related diseases. In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases. Keywords:: hypoxia-inducible factor (HIF), HIF-related disease, HIF competitor, HIF inhibitor |
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| Item Description: | 1347-8613 10.1254/jphs.94.221 |