Risk Factors and Clinical Outcomes of 54 Cases of Rectal Neuroendocrine Tumors with Incomplete Resection: A Retrospective Single-Center Study

• Main Authors: Li Y (Author), Pan F (Author), Sun G (Author), Wang ZK (Author), Meng K (Author), Peng LH (Author), Lu ZS (Author), Dou Y (Author), Yan B (Author), Liu QS (Author)
• Format: Book
• Published: Dove Medical Press, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1178-203X
• Keywords: rnets; endoscopic treatment; incomplete resection; risk factors; follow-up management; Therapeutics. Pharmacology; RM1-950
• Source: Therapeutics and Clinical Risk Management, Vol Volume 17, Pp 1153-1161 (2021)

Yan Li,&ast; Fei Pan,&ast; Gang Sun, Zi-kai Wang, Ke Meng, Li-hua Peng, Zhong-sheng Lu, Yan Dou, Bin Yan, Qing-sen Liu Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, People's Republic of China&ast;These authors contributed equally to this workCorrespondence: Qing-sen Liu; Gang SunDepartment of Gastroenterology, Chinese PLA General Hospital, 28# Fuxing Road, Beijing, 100853, People's Republic of ChinaTel/Fax [phone]Email [e-mail]; [e-mail]: The present study aimed to analyze the risk factors and clinical outcomes of the incomplete endoscopic resection of rectal neuroendocrine tumors (rNETs).Methods: This study retrospectively analyzed the cases of 428 patients with rNETs who had undergone endoscopic treatment in the Department of Gastroenterology at the PLA General Hospital, China, between January 2010 and September 2019.Results: Of the 428 patients with rNETs, 266 were men (62.1%) and 162 were women (37.9%). Of these, 54 had been pathologically diagnosed with positive incisal margins without lymphatic vessel invasion, and the incomplete resection (R1) rate was 12.6%. Among the R1 patients, 28 had received endoscopic submucosal dissection, 22 had received endoscopic mucosal resection, two had received snare resection, and two had undergone removal with forceps. In addition, there were 31 cases of grade G1 R1 resection (11.2%; 31/277), 13 cases of grade G2 R1 resection (23.2%; 13/56), and 10 cases whose grading was not described. The univariate analysis showed the pathological grade was statistically correlated with R1 resection (P < 0.05), and the grade G2 R1 resection rate was higher than that of grade G1. The multivariate logistic regression analysis showed that grade G2 was an independent risk factor leading to R1 resection (P = 0.02). All patients with R1 resection were followed up for 10- 110 months, with an average of 38 months. No salvage treatment was performed. The endoscopic monitoring showed there were no recurrences during the follow-up period.Conclusion: Endoscopic resection is a good option for rNETs, with a high complete resection rate and good prognosis, with rare recurrence even if endoscopic resection is not complete.Keywords: rNETs, endoscopic treatment, incomplete resection, risk factors, follow-up management