Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence
Abstract Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant m...
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| Format: | Book |
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Adis, Springer Healthcare,
2018-12-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_489c3da2d18e4a79b07bd0a926465fc0 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Evelyn Yu-Xin Tay |e author |
| 700 | 1 | 0 | |a Yee-Leng Teoh |e author |
| 700 | 1 | 0 | |a Matthew Sze-Wei Yeo |e author |
| 245 | 0 | 0 | |a Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence |
| 260 | |b Adis, Springer Healthcare, |c 2018-12-01T00:00:00Z. | ||
| 500 | |a 10.1007/s13555-018-0277-7 | ||
| 500 | |a 2193-8210 | ||
| 500 | |a 2190-9172 | ||
| 520 | |a Abstract Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. The introduction of a novel class of drugs, the Hedgehog pathway inhibitors, into clinical practice has ushered in a new treatment algorithm for the treatment of difficult BCC cases. In this review we present the latest available evidence and discuss areas for further research in this rapidly evolving field. | ||
| 546 | |a EN | ||
| 690 | |a Basal cell carcinoma | ||
| 690 | |a Hedgehog pathway inhibitors | ||
| 690 | |a Skin malignancy | ||
| 690 | |a Sonidegib | ||
| 690 | |a Vismodegib | ||
| 690 | |a Dermatology | ||
| 690 | |a RL1-803 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Dermatology and Therapy, Vol 9, Iss 1, Pp 33-49 (2018) | |
| 787 | 0 | |n http://link.springer.com/article/10.1007/s13555-018-0277-7 | |
| 787 | 0 | |n https://doaj.org/toc/2193-8210 | |
| 787 | 0 | |n https://doaj.org/toc/2190-9172 | |
| 856 | 4 | 1 | |u https://doaj.org/article/489c3da2d18e4a79b07bd0a926465fc0 |z Connect to this object online. |