Co-enrichment of CD8-positive T cells and macrophages is associated with clinical benefit of tislelizumab in solid tumors

• Main Authors: Dingwei Ye (Author), Jayesh Desai (Author), Jingwen Shi (Author), Si-Yang Maggie Liu (Author), Wei Shen (Author), Tengfei Liu (Author), Yang Shi (Author), Dan Wang (Author), Liang Liang (Author), Silu Yang (Author), Xiaopeng Ma (Author), Wei Jin (Author), Pei Zhang (Author), Ruiqi Huang (Author), Zhirong Shen (Author), Yun Zhang (Author), Yi-Long Wu (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Activated immune cells (IC) in the tumor microenvironment (TME) are critical for anti-tumor efficacy. Greater understanding of the dynamic diversity and crosstalk between IC is needed to clarify their association with immune checkpoint inhibitor efficacy. Methods Patients from th...