Etiological study of microcytic hypochromic anemia

• Main Authors: S Kafle (Author), M Lakhey (Author)
• Format: Book
• Published: Association of Clinical Pathologists of Nepal, 2016-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p><strong>Background: </strong><span>Microcytic hypochromic anemia is a distinct morphologic subtype of anemia with well- </span><span>de ned etiology and treatment. The objective of this study was to determine the etiology and frequency </span><span>of microcytic hypochromic anemia. </span></p><p><strong>Materials and Methods: </strong><span>This cross-sectional observational study was conducted at Kathmandu </span><span>Medical College Teaching Hospital. One hundred cases of microcytic hypochromic anemia were </span><span>included. Relevant clinical history, hemogram, reticulocyte count, iron pro les were documented in a proforma. Bone marrow aspiration and hemoglobin electrophoresis was conducted when required. Data </span><span>was analysed by Microsoft SPSS 16 windows. </span></p><p><strong>Result: </strong><span>Iron de ciency was the commonest etiology (49%). Dysfunctional uterine bleeding (20.8%) was the commonest cause of iron de ciency, malignancy (24.3%) was the commonest cause of anemia of chronic disease. Mean value of Mean Corpuscular Volume was lowest in hemolytic anemia (71.0 ). Mean Red cell Distribution Width was normal (14.0%) in hemolytic anemia but was raised in other types. Mean serum iron was reduced in iron de ciency anemia (32.2μg/dl) and chronic disease (34.8μg/dl), normal in hemolytic anemia (83μg/dl) and raised in sideroblastic anemia (295μg/dl). Mean serum ferritin was reduced in iron de ciency anemia (7.6ng/ml), raised in chronic disease (158.6ng/ml) and normal in hemolytic anemia (99.2ng/ml). Serum ferritin was normal in sideroblastic anemia (93ng/ml). Mean Total Iron Binding Capacity was raised in iron de ciency anemia (458μg/dl) and normal in other microcytic </span><span>hypochromic anemias. </span></p><p><span><strong>Conclusion:</strong> </span><span>Diagnosis of microcytic hypochromic anemia requires a standardized approach which includes clinical details, hemogram, peripheral blood smear, reticulocyte count, iron pro le, hemoglobin </span><span>electrophoresis and bone marrow examination. </span></p></div></div></div></div>

Item Description

2091-0797
2091-0908
10.3126/jpn.v6i12.16280