Nanoparticles-based anti-aging treatment of Alzheimer's disease

Age is the strongest risk factor for Alzheimer's disease (AD). In recent years, the relationship between aging and AD has been widely studied, with anti-aging therapeutics as the treatment for AD being one of the mainstream research directions. Therapeutics targeting senescent cells have shown...

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Main Authors: Jian-Jian Chu (Author), Wen-Bo Ji (Author), Jian-Hua Zhuang (Author), Bao-Feng Gong (Author), Xiao-Han Chen (Author), Wen-Bin Cheng (Author), Wen-Danqi Liang (Author), Gen-Ru Li (Author), Jie Gao (Author), You Yin (Author)
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Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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100 1 0 |a Jian-Jian Chu  |e author 
700 1 0 |a Wen-Bo Ji  |e author 
700 1 0 |a Jian-Hua Zhuang  |e author 
700 1 0 |a Bao-Feng Gong  |e author 
700 1 0 |a Xiao-Han Chen  |e author 
700 1 0 |a Wen-Bin Cheng  |e author 
700 1 0 |a Wen-Danqi Liang  |e author 
700 1 0 |a Gen-Ru Li  |e author 
700 1 0 |a Jie Gao  |e author 
700 1 0 |a You Yin  |e author 
245 0 0 |a Nanoparticles-based anti-aging treatment of Alzheimer's disease 
260 |b Taylor & Francis Group,   |c 2022-12-01T00:00:00Z. 
500 |a 10.1080/10717544.2022.2094501 
500 |a 1521-0464 
500 |a 1071-7544 
520 |a Age is the strongest risk factor for Alzheimer's disease (AD). In recent years, the relationship between aging and AD has been widely studied, with anti-aging therapeutics as the treatment for AD being one of the mainstream research directions. Therapeutics targeting senescent cells have shown improvement in AD symptoms and cerebral pathological changes, suggesting that anti-aging strategies may be a promising alternative for AD treatment. Nanoparticles represent an excellent approach for efficiently crossing the blood-brain barrier (BBB) to achieve better curative function and fewer side effects. Thereby, nanoparticles-based anti-aging treatment may exert potent anti-AD therapeutic efficacy. This review discusses the relationship between aging and AD and the application and prospect of anti-aging strategies and nanoparticle-based therapeutics in treating AD. 
546 |a EN 
690 |a AD 
690 |a anti-aging 
690 |a BBB 
690 |a nanoparticles 
690 |a senescent cells 
690 |a anti-inflammation 
690 |a Therapeutics. Pharmacology 
690 |a RM1-950 
655 7 |a article  |2 local 
786 0 |n Drug Delivery, Vol 29, Iss 1, Pp 2100-2116 (2022) 
787 0 |n https://www.tandfonline.com/doi/10.1080/10717544.2022.2094501 
787 0 |n https://doaj.org/toc/1071-7544 
787 0 |n https://doaj.org/toc/1521-0464 
856 4 1 |u https://doaj.org/article/4924e23444f245ee83e5ec1e2a7f4e5b  |z Connect to this object online.