Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy
Abstract Background The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. Main body This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around...
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| Main Authors: | , |
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| Format: | Book |
| Published: |
SpringerOpen,
2020-07-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Abstract Background The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. Main body This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus. Conclusion The linker group and substitution at N-1, C-2, C-5, and C-6 positions have been found to be the most contributory factors for anticancer activity. This will help in the further design to afford more selective, potent, and multi-target anticancer of 2-substituted benzimidazole-based compounds. |
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| Item Description: | 10.1186/s43094-020-00048-8 2314-7253 |