Synthesis of Some Heterocyclic Compounds Containing Tetrahydroisoquinoline Moiety
<strong>ABSTRACT</strong><br /> <strong> </strong>This research involves synthesis of some five membered heterocyclic compounds using 1,2,3,4-tetrahydroisoquinoline as a synthone. The initial step in this research involves the reaction of 1,2,3,4-tetrahydroisoquino...
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| Format: | Book |
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College of Education for Pure Sciences,
2013-12-01T00:00:00Z.
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| Summary: | <strong>ABSTRACT</strong><br /> <strong> </strong>This research involves synthesis of some five membered heterocyclic compounds using 1,2,3,4-tetrahydroisoquinoline as a synthone. The initial step in this research involves the reaction of 1,2,3,4-tetrahydroisoquinoline with ethyl chloroacetate to form ethyl α-(1,2,3,4-tetrahydroisoquinolin-2-yl) acetate (1), which was converted to the hydrazide (2). This hydrazide was used to prepare some heterocyclic compounds, such as substituted oxadiazoles (7-10, 23) and thiadiazoles (11-14) via preparation of intermediate compounds such as diacylhydrazines (3-6), hydrazones (15-18) and substituted oxadiazoline compounds (19-22) and (24-27). The synthesized compounds were identified on the basis of some physical and IR spectral data. |
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| Item Description: | 1812-125X 2664-2530 10.33899/edusj.2013.163063 |