Nalbuphine Potentiates Reversal of Fentanyl Overdose by Naloxone

• Main Authors: Mihai Cernea (Author), Georgiy Nikonov (Author), Janna Ataiants (Author), Cristina Ştefănuţ (Author), John Abernethy (Author), Michael Voronkov (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Developing an effective antidote for fentanyl-induced overdose to achieve timely reversal is an unmet public health need. Previously, we found that naloxone derivative NX90 with mild κ-opioid agonistic properties was three-fold more effective than the parent naloxone in reversing a fentanyl overdose...