Relationship between HLA-DRB1 alleles and onychomycosis in Chinese Han population in Guangdong province
Objective: To investigate the relationship between polymorphism of human leukocyte antigen (HLA)-DRB1 alleles and onychomycosis in Chinese Han population in Guangdong province. Methods: Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was adopted to detect the allele frequenci...
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| Main Authors: | , , , , |
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| Format: | Book |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology,
2020-10-01T00:00:00Z.
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| Summary: | Objective: To investigate the relationship between polymorphism of human leukocyte antigen (HLA)-DRB1 alleles and onychomycosis in Chinese Han population in Guangdong province. Methods: Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was adopted to detect the allele frequencies of HLA-DRB1 in 64 cases of onychomycosis, including 10 cases of Trichophyton rubrum infection, and 64 healthy controls. The differences in allele frequencies were compared between patients and controls. Results: The allele frequencies of HLA-DRB1*10 in Han patients with onychomycosis were higher than that in the controls (χ2=5.10, P<0.05). In contrast, the allele frequencies of HLA-DRB1*12 in Han patients with trichophyton rubrum infection were lower than that in the controls (χ2=4.70, P<0.05). Conclusions: HLA-DRB1*10 alleles may be the susceptibility gene of onychomycosis in Chinese Han population in Guangdong province. HLA-DRB1*12 alleles could prevent the development of onychomycosis caused by trichophyton rubrum. HLA alleles could be immunogenetically associated with onychomycosis. |
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| Item Description: | 1674-8468 10.3969/j.issn.1674-8468.2020.05.003 |