The Bioactive Phenolic Agents Diaryl Ether CVB2-61 and Diarylheptanoid CVB4-57 as Connexin Hemichannel Blockers

• Main Authors: Anne Dierks (Author), Corinne Vanucci-Bacqué (Author), Anne-Marie Schäfer (Author), Tina Lehrich (Author), Frederike Ruhe (Author), Patrik Schadzek (Author), Florence Bedos-Belval (Author), Anaclet Ngezahayo (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation mediators enhance the activity of connexin (Cx) hemichannels, especially in the epithelial and endothelial tissues. As potential release routes for injury signals, such as (oligo)nucleotides, Cx hemichannels may contribute to long-lasting inflammation. Specific inhibition of Cx hemichan...