Effect of the versatile bifunctional chelator AAZTA5 on the radiometal labelling properties and the in vitro performance of a gastrin releasing peptide receptor antagonist

• Main Authors: Michael Hofstetter (Author), Euy Sung Moon (Author), Fabio D'Angelo (Author), Lucien Geissbühler (Author), Ian Alberts (Author), Ali Afshar-Oromieh (Author), Frank Rösch (Author), Axel Rominger (Author), Eleni Gourni (Author)
• Format: Book
• Published: SpringerOpen, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Gastrin Releasing Peptide receptor (GRPr)-based radioligands have shown great promise for diagnostic imaging of GRPr-positive cancers, such as prostate and breast. The present study aims at developing and evaluating a versatile GRPr-based probe for both PET/SPECT imaging as well...