A Prospective observational study of single-dose prophylactic antibiotic in caesarean delivery and its effect on maternal infectious morbidity

• Main Authors: Shreedevi Kori (Author), Aruna Biradar (Author), Dayanand Biradar (Author), Subhash Chandra R Mudanur (Author), Neelamma Patil (Author), Rajasri Yaliwal (Author), H S Sridevi (Author), Susmitha Jada (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2468-838X; 2456-1975; 10.4103/2468-838X.303804
• Keywords: surgical site infections; postoperative fever; endometritis; Therapeutics. Pharmacology; RM1-950
• Source: BLDE University Journal of Health Sciences, Vol 5, Iss 3, Pp 44-45 (2020)

Introduction: Caserean delivery is the most commonly performed in obstetrics. Antibiotics have revolutionised the surgical practice in this era. But multidrug resistance is a challenging issue in practice. So antibiotics have to be administered judiciously at the appropriate time with respect to surgery. Aim: To determine whether the administration of single-dose injection ceftriaxone 1gm intravenously prior to skin incision was superior to the administration at the time of cord clamping for prevention of post-caesarean maternal infectious. Material and Methods: A prospective observational study was conducted in BLDE (DU) Shri B M Patil medical college and research centre, Vijayapura, Karnataka. Patients undergoing caesarean sections for singleton term pregnancies both elective and emergency with intact membranes were included in the study during the one-year period. Alternatively, Group A received 1gm Injection ceftriaxone intravenously 60 mins before skin incision and group B received at the time of cord clamping during surgery. Results: Incidence of obstetric complications such as nausea (0.5% vs 0.0%) and wound infections (6.6% vs 4.1%) were more in patients received a single dose of ceftriaxone at cord clamping than patients received the same antibiotic, preoperatively. Whereas, the incidence of postoperative fever was more in patients received a single dose of ceftriaxone preoperatively (4.1%) than intraoperatively (3.3%) which was although not significant but is an important finding in our study. Conclusion: Administration of single-dose antibiotic either preoperatively or at the time of cord clamping was not statistically significant in reducing the incidence of wound infections. However, we noticed that the antibiotic administration pre-operatively reduced the infections compared to the cord clamp group.