GlicoPro, Novel Standardized and Sterile Snail Mucus Extract for Multi-Modulative Ocular Formulations: New Perspective in Dry Eye Disease Management
This study aimed to evaluate the mucoadhesive and regenerative properties of a novel lubricating multimolecular ophthalmic solution (GlicoPro<sup>®</sup>) extracted from snail mucus and its potential anti-inflammatory and analgesic role in the management of dry eye disease (DED). GlicoPr...
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| Format: | Book |
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MDPI AG,
2021-12-01T00:00:00Z.
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|---|---|---|---|
| 001 | doaj_4a2ea23b11cf46f6b71ed09156656a29 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Rita Mencucci |e author |
| 700 | 1 | 0 | |a Giovanni Strazzabosco |e author |
| 700 | 1 | 0 | |a Virginia Cristofori |e author |
| 700 | 1 | 0 | |a Andrea Alogna |e author |
| 700 | 1 | 0 | |a Daria Bortolotti |e author |
| 700 | 1 | 0 | |a Roberta Gafà |e author |
| 700 | 1 | 0 | |a Michela Cennamo |e author |
| 700 | 1 | 0 | |a Eleonora Favuzza |e author |
| 700 | 1 | 0 | |a Claudio Trapella |e author |
| 700 | 1 | 0 | |a Valentina Gentili |e author |
| 700 | 1 | 0 | |a Roberta Rizzo |e author |
| 245 | 0 | 0 | |a GlicoPro, Novel Standardized and Sterile Snail Mucus Extract for Multi-Modulative Ocular Formulations: New Perspective in Dry Eye Disease Management |
| 260 | |b MDPI AG, |c 2021-12-01T00:00:00Z. | ||
| 500 | |a 10.3390/pharmaceutics13122139 | ||
| 500 | |a 1999-4923 | ||
| 520 | |a This study aimed to evaluate the mucoadhesive and regenerative properties of a novel lubricating multimolecular ophthalmic solution (GlicoPro<sup>®</sup>) extracted from snail mucus and its potential anti-inflammatory and analgesic role in the management of dry eye disease (DED). GlicoPro bio-adhesive efficacy was assessed using a lectin-based assay, and its regenerative properties were studied in a human corneal epithelial cell line. In vitro DED was induced in human corneal tissues; the histology and mRNA expression of selected genes of inflammatory and corneal damage biomarkers were analyzed in DED tissues treated with GlicoPro. A higher percentage of bio-adhesivity was observed in corneal cells treated with GlicoPro than with sodium hyaluronate-based compounds. In the scratch test GlicoPro improved in vitro corneal wound healing. Histo-morphological analysis revealed restoration of cellular organization of the corneal epithelium, microvilli, and mucin network in DED corneal tissues treated with GlicoPro. A significant reduction in inflammatory and ocular damage biomarkers was observed. High-performance liquid chromatography-mass spectrometry analysis identified an endogenous opioid, opiorphin, in the peptide fraction of GlicoPro. In conclusion, GlicoPro induced regeneration and bio-adhesivity in corneal cells; moreover, considering its anti-inflammatory and analgesic properties, this novel ophthalmic lubricating solution may be an innovative approach for the management of DED. | ||
| 546 | |a EN | ||
| 690 | |a dry eye disease | ||
| 690 | |a snail mucus | ||
| 690 | |a opiorphin | ||
| 690 | |a artificial tears | ||
| 690 | |a corneal epithelium | ||
| 690 | |a Pharmacy and materia medica | ||
| 690 | |a RS1-441 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Pharmaceutics, Vol 13, Iss 12, p 2139 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/1999-4923/13/12/2139 | |
| 787 | 0 | |n https://doaj.org/toc/1999-4923 | |
| 856 | 4 | 1 | |u https://doaj.org/article/4a2ea23b11cf46f6b71ed09156656a29 |z Connect to this object online. |