Modelling amoebic brain infection caused by Balamuthia mandrillaris using a human cerebral organoid.

• Main Authors: Nongnat Tongkrajang (Author), Porntida Kobpornchai (Author), Pratima Dubey (Author), Urai Chaisri (Author), Kasem Kulkeaw (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lack of disease models adequately resembling human tissue has hindered our understanding of amoebic brain infection. Three-dimensional structured organoids provide a microenvironment similar to human tissue. This study demonstrates the use of cerebral organoids to model a rare brain infection ca...