ALT Trends through Childhood and Adolescence Associated with Hepatic Steatosis at 24 Years: A Population-Based UK Cohort Study
(1) Background: Alanine aminotransferase (ALT) is used to screen for non-alcoholic fatty liver disease (NAFLD) in children; however, the optimal age to commence screening is not determined. Our objective was to describe whether ALT trends from 9-24 years were associated with hepatic steatosis at 24...
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MDPI AG,
2020-09-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_4a4085c9de314f8288f55720b0c7bb18 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Ahlia Sekkarie |e author |
| 700 | 1 | 0 | |a Jean A. Welsh |e author |
| 700 | 1 | 0 | |a Kate Northstone |e author |
| 700 | 1 | 0 | |a Catherine E. Cioffi |e author |
| 700 | 1 | 0 | |a Aryeh D. Stein |e author |
| 700 | 1 | 0 | |a Janet Figueroa |e author |
| 700 | 1 | 0 | |a Usha Ramakrishnan |e author |
| 700 | 1 | 0 | |a Miriam B. Vos |e author |
| 245 | 0 | 0 | |a ALT Trends through Childhood and Adolescence Associated with Hepatic Steatosis at 24 Years: A Population-Based UK Cohort Study |
| 260 | |b MDPI AG, |c 2020-09-01T00:00:00Z. | ||
| 500 | |a 10.3390/children7090117 | ||
| 500 | |a 2227-9067 | ||
| 520 | |a (1) Background: Alanine aminotransferase (ALT) is used to screen for non-alcoholic fatty liver disease (NAFLD) in children; however, the optimal age to commence screening is not determined. Our objective was to describe whether ALT trends from 9-24 years were associated with hepatic steatosis at 24 years in a population-based UK cohort. (2) Methods: The sample included 1156 participants who were assessed for hepatic steatosis at 24 years and had at least two ALT measurements at 9, 15, 17, and/or 24 years. Controlled attenuation parameter scores were used to assess steatosis (low (<248 dB/m), mild/moderate (248-279 dB/m), severe (>279 dB/m)). Sex-stratified mixed-effects models were constructed to assess the liver enzyme trends by steatosis level. (3) Results: The final sample was 41.4% male and 10.4% had severe steatosis. In both sexes, ALT trends from 9 to 24 years differed in those with low vs. severe steatosis at 24 years (<i>p</i> < 0.001). There was no evidence of differences prior to puberty. At 17 years, the low vs. severe geometric mean ratio (GMR) was 0.69, 95% CI: 0.57-0.85 in males and (0.81, 0.65-1.01) females. At 24 years, the GMR was (0.53, 0.42-0.66) in males and (0.67, 0.54-0.84) females. (4) Conclusions: Higher ALT concentration in adolescence was associated with hepatic steatosis at 24 years. The increased screening of adolescents could strengthen NAFLD prevention and treatment efforts. | ||
| 546 | |a EN | ||
| 690 | |a NAFLD | ||
| 690 | |a ALT | ||
| 690 | |a childhood | ||
| 690 | |a longitudinal | ||
| 690 | |a ALSPAC | ||
| 690 | |a Pediatrics | ||
| 690 | |a RJ1-570 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Children, Vol 7, Iss 9, p 117 (2020) | |
| 787 | 0 | |n https://www.mdpi.com/2227-9067/7/9/117 | |
| 787 | 0 | |n https://doaj.org/toc/2227-9067 | |
| 856 | 4 | 1 | |u https://doaj.org/article/4a4085c9de314f8288f55720b0c7bb18 |z Connect to this object online. |