Apoptotic colopathy following bendamustine therapy
A 60-year-old woman with marginal zone lymphoma was treated with obinutuzumab and bendamustine after failing rituximab. She later developed intractable nausea and diarrhea which resulted in a dramatic weight loss and multiple hospitalizations. During her hospital stay the patient had a colonoscopy a...
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| Main Authors: | , , |
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| Format: | Book |
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Elsevier,
2023-11-01T00:00:00Z.
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| Summary: | A 60-year-old woman with marginal zone lymphoma was treated with obinutuzumab and bendamustine after failing rituximab. She later developed intractable nausea and diarrhea which resulted in a dramatic weight loss and multiple hospitalizations. During her hospital stay the patient had a colonoscopy and biopsy which identified apoptotic colopathy- a pathologic condition characterized histologically by apoptosis. Her apoptotic colopathy was ultimately attributed to bendamustine, a previously unidentified trigger of apoptotic colopathy. The patient was eventually discharged on total parenteral nutrition (TPN) and has regained weight with adequate control of her diarrhea. |
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| Item Description: | 2772-736X 10.1016/j.hpr.2023.300720 |