Type I Interferon, Induced by Adenovirus or Adenoviral Vector Infection, Regulates the Cytokine Response to Lipopolysaccharide in a Macrophage Type-Specific Manner

• Main Authors: Mareike D. Maler (Author), Sophie Zwick (Author), Carsten Kallfass (Author), Peggy Engelhard (Author), Hexin Shi (Author), Laura Hellig (Author), Pang Zhengyang (Author), Annika Hardt (Author), Gernot Zissel (Author), Zsolt Ruzsics (Author), Willi Jahnen-Dechent (Author), Stefan F. Martin (Author), Peter Jess Nielsen (Author), Daiana Stolz (Author), Justyna Lopatecka (Author), Sarah Bastyans (Author), Bruce Beutler (Author), Wolfgang W. Schamel (Author), György Fejer (Author), Marina Alexandra Freudenberg (Author)
• Format: Book
• Published: Karger Publishers, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: While TLR ligands derived from microbial flora and pathogens are important activators of the innate immune system, a variety of factors such as intracellular bacteria, viruses, and parasites can induce a state of hyperreactivity, causing a dysregulated and potentially life-threatening...