Reintroduction of nitrofurantoin in the treatment of uncomplicated urinary tract infection

• Main Authors: Sabiha Mahboob (Author), Md. Sayedur Rahman (Author)
• Format: Book
• Published: Bangladesh Pharmacological Society, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 10.3329/bjp.v16i3.54481; 1991-0088
• Keywords: Nitrofurantoin; Uncomplicated urinary tract infection; Therapeutics. Pharmacology; RM1-950
• Source: Bangladesh Journal of Pharmacology, Vol 16, Iss 3 (2021)

The present study was designed to reintroduce an older antimicrobial nitrofurantoin among a group of prescribers and to explore the relationship between the reintroduction and corresponding shift in sensitivity pattern of the microbes. The microbial sensitivity against ciprofloxacin before intervention was 46.6%, which significantly increased after intervention (51.8%). Treatment with nitrofurantoin resulted in a total clinical cure rate of 80.6%, of which rate of clinical cure achieved in expected time was 66.1% and delayed was 14.5%. The rate of total clinical cure with nitrofurantoin corresponded closely with the proportion of urinary isolates sensitive to nitrofurantoin. i.e., 86.3%. This preliminary study revealed that revival might be an effective strategy to increase the sensitivity and to delay the emergence of resistance.