CCR5 is a novel target for the treatment of experimental alopecia areata

• المؤلفون الرئيسيون: Taisuke Ito (مؤلف), Takahiro Suzuki (مؤلف), Atsuko Funakoshi (مؤلف), Toshiharu Fujiyama (مؤلف), Yoshiki Tokura (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Alopecia areata (AA) is an organ‐specific and cell‐mediated autoimmune disease. Hair follicle autoantigens are disclosed to these autoreactive NKG2D+CD8+ T cells. A Th1 chemokine, CXCL10, is highly expressed on hair follicle keratinocytes and leads to the infiltration of CXCR3+ a...