CCR5 is a novel target for the treatment of experimental alopecia areata

• Main Authors: Taisuke Ito (Author), Takahiro Suzuki (Author), Atsuko Funakoshi (Author), Toshiharu Fujiyama (Author), Yoshiki Tokura (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Alopecia areata (AA) is an organ‐specific and cell‐mediated autoimmune disease. Hair follicle autoantigens are disclosed to these autoreactive NKG2D+CD8+ T cells. A Th1 chemokine, CXCL10, is highly expressed on hair follicle keratinocytes and leads to the infiltration of CXCR3+ a...