Design and Synthesis of Small Molecules as Potent <i>Staphylococcus aureus</i> Sortase A Inhibitors
The widespread and uncontrollable emergence of antibiotic-resistant bacteria, especially methicillin-resistant <i>Staphylococcus aureus</i>, has promoted a wave of efforts to discover a new generation of antibiotics that prevent or treat bacterial infections neither as bactericides nor b...
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| Main Authors: | , , |
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| Format: | Book |
| Published: |
MDPI AG,
2020-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | The widespread and uncontrollable emergence of antibiotic-resistant bacteria, especially methicillin-resistant <i>Staphylococcus aureus</i>, has promoted a wave of efforts to discover a new generation of antibiotics that prevent or treat bacterial infections neither as bactericides nor bacteriostats. Due to its crucial role in virulence and its nonessentiality in bacterial survival, sortase A has been considered as a great target for new antibiotics. Sortase A inhibitors have emerged as promising alternative antivirulence agents against bacteria. Herein, the structural and preparative aspects of some small synthetic organic compounds that block the pathogenic action of sortase A have been described. |
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| Item Description: | 10.3390/antibiotics9100706 2079-6382 |