Synthesis of 1,3,4-Oxadiazole Derivatives from Ethyl-2-Piperidone-3-Carboxylate
ABSTRACT<br /> In the present work, some new 1,3,4- Oxadiazole derivatives have been synthesized from Ethyl-2-Piperidone-3-Carboxylate. The reaction of the ethyl ester with hydrazine hydrate afforded the corresponding hydrazide (I). Treatment of the latter compound with different aromatic alde...
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| Main Authors: | , |
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| Formato: | Livro |
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College of Education for Pure Sciences,
2012-03-01T00:00:00Z.
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| Resumo: | ABSTRACT<br /> In the present work, some new 1,3,4- Oxadiazole derivatives have been synthesized from Ethyl-2-Piperidone-3-Carboxylate. The reaction of the ethyl ester with hydrazine hydrate afforded the corresponding hydrazide (I). Treatment of the latter compound with different aromatic aldehydes yielded a new hydrazones (II). Preparation of 1,3,4- Oxadiazoles (III) have been achieved by oxidative cyclization of hydrazones (II) by the use of lead dioxide in glacial acetic acid. <br /> The structural formula of the synthesized compounds were established by physical and spectral methods. |
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| Descrição do item: | 1812-125X 2664-2530 10.33899/edusj.2012.58997 |