Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma

• Main Authors: Li Peng (Author), Yanyi Jiang (Author), Hengxing Chen (Author), Yongqiang Wang (Author), Qiusheng Lan (Author), Shuiqin Chen (Author), Zhanwang Huang (Author), Jingyuan Zhang (Author), Duanqing Tian (Author), Yuntan Qiu (Author), Diankui Cai (Author), Jiangyun Peng (Author), Daning Lu (Author), Xiaoqing Yuan (Author), Xianzhu Yang (Author), Dong Yin (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transcriptional dysregulation of genes is a hallmark of tumors and can serve as targets for cancer drug development. However, it is extremely challenging to develop small-molecule inhibitors to target abnormally expressed transcription factors (TFs) except for the nuclear receptor family of TFs. Lit...