Postpartum microangiopathic disorders: A case report and review of the literature
Introduction: Thrombotic microangiopathic disorders (TMA's) consist of five overlapping disorders: severe pre-eclampsia; HELLP (haemolysis, elevated liver enzyme, and low platelet count) syndrome; thrombotic thrombocytopenic purpura (TTP); haemolytic-uremic syndrome (HUS) and systemic lupus ery...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2014-07-01T00:00:00Z.
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| Summary: | Introduction: Thrombotic microangiopathic disorders (TMA's) consist of five overlapping disorders: severe pre-eclampsia; HELLP (haemolysis, elevated liver enzyme, and low platelet count) syndrome; thrombotic thrombocytopenic purpura (TTP); haemolytic-uremic syndrome (HUS) and systemic lupus erythematosus (SLE). Although several case reports are published on TTP during pregnancy, none of them has described TTP in the postpartum period. Case presentation: We present a case report that illustrates the clinical difficulties and uncertainties in diagnosing TTP in a peripartum period. After repeatedly borderline ADAMTS13 tests and deteriorating TMA abnormalities in the first 72 h postpartum, treatment with plasma filtration, fresh frozen plasma and prednisolone resulted in a quick clinical and laboratory response. Conclusion: Treatment for TTP should be strongly considered in case of an on-going TMA more than 72 h after delivery. |
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| Item Description: | 2214-9112 10.1016/j.crwh.2014.08.001 |