Association of serum uric acid level with coronary artery stenosis severity in Korean end-stage renal disease patients

Background: Hyperuricemia is common in end-stage renal disease (ESRD) patients, and many previous studies have reported the associations between hyperuricemia and adverse cardiovascular outcomes, which are the major cause of death in such patients. We investigated the relationship between serum uric...

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Main Authors: Hye Yun Jeong (Author), Hye Jeong Cho (Author), Sang Hoon Kim (Author), Jun Chul Kim (Author), Mi Jung Lee (Author), Dong Ho Yang (Author), So-Young Lee (Author)
Format: Book
Published: The Korean Society of Nephrology, 2017-09-01T00:00:00Z.
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LEADER 00000 am a22000003u 4500
001 doaj_4b46fc92b5af44a6b56e48ec3c4858df
042 |a dc 
100 1 0 |a Hye Yun Jeong  |e author 
700 1 0 |a Hye Jeong Cho  |e author 
700 1 0 |a Sang Hoon Kim  |e author 
700 1 0 |a Jun Chul Kim  |e author 
700 1 0 |a Mi Jung Lee  |e author 
700 1 0 |a Dong Ho Yang  |e author 
700 1 0 |a So-Young Lee  |e author 
245 0 0 |a Association of serum uric acid level with coronary artery stenosis severity in Korean end-stage renal disease patients 
260 |b The Korean Society of Nephrology,   |c 2017-09-01T00:00:00Z. 
500 |a 2211-9132 
500 |a 10.23876/j.krcp.2017.36.3.282 
520 |a Background: Hyperuricemia is common in end-stage renal disease (ESRD) patients, and many previous studies have reported the associations between hyperuricemia and adverse cardiovascular outcomes, which are the major cause of death in such patients. We investigated the relationship between serum uric acid level and the severity of coronary stenosis in ESRD patients on maintenance hemodialysis (MHD). Methods: Among 721 patients who started MHD treatment, 102 underwent coronary angiographic tests complaining of chest discomfort that was new at initiation of MHD. We collected data on uric acid level and coronary artery luminal diameter, defining luminal diameter narrowing of more than 50% in any major coronary artery as critical-stenosis. Results: We detected critical coronary artery stenosis in 52 (57.8%) patients. The mean uric acid level was 6.6 ± 2.2 mg/dL, and that was significantly higher in the critical-stenosis group (4.9 ± 1.4 mg/dL vs. 7.8 ± 2.0 mg/dL, P < 0.001). The only independent predictor of critical-stenosis in multivariate analysis was serum uric acid level (P < 0.001). Conclusion: High serum uric acid was associated with severe coronary artery stenosis in Korean ESRD patients. Hyperuricemia is a readily modifiable factor, and appropriately preventing it could provide significant benefits in ESRD patients. 
546 |a EN 
546 |a KO 
690 |a Cardiovascular diseases 
690 |a Chronic kidney disease 
690 |a Coronary stenosis 
690 |a Renal dialysis 
690 |a Uric acid 
690 |a Internal medicine 
690 |a RC31-1245 
690 |a Specialties of internal medicine 
690 |a RC581-951 
655 7 |a article  |2 local 
786 0 |n Kidney Research and Clinical Practice, Vol 36, Iss 3, Pp 282-289 (2017) 
787 0 |n https://doi.org/10.23876/j.krcp.2017.36.3.282 
787 0 |n https://doaj.org/toc/2211-9132 
856 4 1 |u https://doaj.org/article/4b46fc92b5af44a6b56e48ec3c4858df  |z Connect to this object online.