Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis.

• Main Authors: Jéssica Cristina Dos Santos (Author), Valéria Bernadete Leite Quixabeira (Author), Muriel Vilela Teodoro Silva (Author), Michelle S M A Damen (Author), Kiki Schraa (Author), Martin Jaeger (Author), Marije Oosting (Author), Samuel T Keating (Author), Miriam Leandro Dorta (Author), Sebastião Alves Pinto (Author), Fernanda Bugalho Duarte (Author), Ledice Inácia de Araújo Pereira (Author), Mihai G Netea (Author), Fátima Ribeiro-Dias (Author), Leo A B Joosten (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells in vitro, we demonstrate that the expression of IL-32 isoforms is dependent o...