Bone marrow stromal cells reduce low-dose cytarabine-induced differentiation of acute myeloid leukemia

• Автори: Tomislav Smoljo (Автор), Barbara Tomic (Автор), Hrvoje Lalic (Автор), Vilma Dembitz (Автор), Josip Batinic (Автор), Antonio Bedalov (Автор), Dora Visnjic (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Low-dose cytarabine (LDAC) is a standard therapy for elderly acute myeloid leukemia (AML) patients unfit for intensive chemotherapy. While high doses of cytarabine induce cytotoxicity, the precise mechanism of action of LDAC in AML remains elusive. In vitro studies have demonstrated LDAC-induced dif...