Bone marrow stromal cells reduce low-dose cytarabine-induced differentiation of acute myeloid leukemia

• Main Authors: Tomislav Smoljo (Author), Barbara Tomic (Author), Hrvoje Lalic (Author), Vilma Dembitz (Author), Josip Batinic (Author), Antonio Bedalov (Author), Dora Visnjic (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Low-dose cytarabine (LDAC) is a standard therapy for elderly acute myeloid leukemia (AML) patients unfit for intensive chemotherapy. While high doses of cytarabine induce cytotoxicity, the precise mechanism of action of LDAC in AML remains elusive. In vitro studies have demonstrated LDAC-induced dif...