Acid-base and lipophilic properties of peptide nucleic acid derivatives

• Main Authors: Pramod Thakare (Author), Francesca Vasile (Author), Maura Vallaro (Author), Sonja Visentin (Author), Giulia Caron (Author), Emanuela Licandro (Author), Silvia Cauteruccio (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The first combined experimental and theoretical study on the ionization and lipophilic properties of peptide nucleic acid (PNA) derivatives, including eleven PNA monomers and two PNA decamers, is described. The acidity constants (pKa) of individual acidic and basic centers of PNA monomers were measu...