Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness

• Main Authors: Dominik Brücher (Author), Vojtech Franc (Author), Sheena N. Smith (Author), Albert J. R. Heck (Author), Andreas Plückthun (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gene therapy approaches now allow for the production of therapeutic antibodies by healthy or cancerous human tissues directly in vivo, and, with an increasing number of gene delivery methods available, the cell type for expression can be chosen. Yet, little is known about the biophysical changes int...