Evaluation of the Antitumor Activity of Dacomitinib in Models of Human Bladder Cancer

• Main Authors: Petros D. Grivas (Author), Kathleen C. Day (Author), Andreas Karatsinides (Author), Alyssa Paul (Author), Nazia Shakir (Author), Iya Owainati (Author), Monica Liebert (Author), Lakshmi P. Kunju (Author), Dafydd Thomas (Author), Maha Hussain (Author), Mark L. Day (Author)
• Format: Book
• Published: BMC, 2013-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Members of the human epidermal growth factor receptor (HER) family play a significant role in bladder cancer progression and may underlie the development of chemotherapy resistance. Dacomitinib is an irreversible tyrosine kinase inhibitor with structural specificity for the catalytic domain...