Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model

• Autors principals: Catarina Chaves (Autor), Tuan-Minh Do (Autor), Céline Cegarra (Autor), Valérie Roudières (Autor), Sandrine Tolou (Autor), Gilbert Thill (Autor), Corinne Rocher (Autor), Michel Didier (Autor), Dominique Lesuisse (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2020-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The non-human primate (NHP)-brain endothelium constitutes an essential alternative to human in the prediction of molecule trafficking across the blood-brain barrier (BBB). This study presents a comparison between the NHP transcriptome of freshly isolated brain microcapillaries and in vitro-selected...