<i>Aniba rosaeodora</i> (Var. amazonica Ducke) Essential Oil: Chemical Composition, Antibacterial, Antioxidant and Antitrypanosomal Activity

• Main Authors: Amanda Mara Teles (Author), João Victor Silva-Silva (Author), Juan Matheus Pereira Fernandes (Author), Kátia da Silva Calabrese (Author), Ana Lucia Abreu-Silva (Author), Silvio Carvalho Marinho (Author), Adenilde Nascimento Mouchrek (Author), Victor Elias Mouchrek Filho (Author), Fernando Almeida-Souza (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<i>Aniba rosaeodora</i> is one of the most widely used plants in the perfumery industry, being used as medicinal plant in the Brazilian Amazon. This work aimed to evaluate the chemical composition of <i>A. rosaeodora</i> essential oil and its biological activities. <i>A. rosaeodora</i> essential oil presented linalool (93.60%) as its major compound. The <i>A. rosaeodora</i> essential oil and linalool showed activity against all the bacteria strains tested, standard strains and marine environment bacteria, with the lower minimum inhibitory concentration being observed for <i>S. aureus</i>. An efficient antioxidant activity of <i>A. rosaeodora</i> essential oil and linalool (EC₅₀: 15.46 and 6.78 µg/mL, respectively) was evidenced by the inhibition of the 2,2-azinobis- (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical. The antitrypanosomal activity of <i>A. rosaeodora</i> essential oil and linalool was observed at high concentrations against epimatigote forms (inhibitory concentration for 50% of parasites (IC₅₀): 150.5 ± 1.08 and 198.6 ± 1.12 µg/mL, respectively), and even higher against intracellular amastigotes of <i>T. cruzi</i> (IC₅₀: 911.6 ± 1.15 and 249.6 ± 1.18 µg/mL, respectively). Both <i>A. rosaeodora</i> essential oil and linalool did not exhibit a cytotoxic effect in BALB/c peritoneal macrophages, and both reduced nitrite levels in unstimulated cells revealing a potential effect in NO production. These data revealed the pharmacological potential of <i>A. rosaeodora</i> essential oil and linalool, encouraging further studies.

Item Description

10.3390/antibiotics10010024
2079-6382