Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation

• Main Authors: Shailaja Mahajan-Thakur (Author), Andreas Böhm (Author), Gabriele Jedlitschky (Author), Karsten Schrör (Author), Bernhard H. Rauch (Author)
• Formato: Libro
• Publicado: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Sphingosine-1-phosphate (S1P) is a versatile lipid signaling molecule and key regulator in vascular inflammation. S1P is secreted by platelets, monocytes, and vascular endothelial and smooth muscle cells. It binds specifically to a family of G-protein-coupled receptors, S1P receptors 1 to 5, resulti...