Sanguiin H-6 Fractionated from Cloudberry (<i>Rubus chamaemorus</i>) Seeds Can Prevent the Methicillin-Resistant <i>Staphylococcus aureus</i> Biofilm Development during Wound Infection

• Main Authors: John Jairo Aguilera-Correa (Author), Sara Fernández-López (Author), Iskra Dennisse Cuñas-Figueroa (Author), Sandra Pérez-Rial (Author), Hanna-Leena Alakomi (Author), Liisa Nohynek (Author), Kirsi-Marja (Author), Juha-Pekka Salminen (Author), Jaime Esteban (Author), Juan Cuadros (Author), Riitta Puupponen-Pimiä (Author), Ramon Perez-Tanoira (Author), Teemu J. Kinnari (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<i>Staphylococcus aureus</i> is the most common cause of surgical site infections and its treatment is challenging due to the emergence of multi-drug resistant strains such as methicillin-resistant <i>S. aureus</i> (MRSA). Natural berry-derived compounds have shown antimicrobial potential, e.g., ellagitannins such as sanguiin H-6 and lambertianin C, the main phenolic compounds in <i>Rubus</i> seeds, have shown antimicrobial activity. The aim of this study was to evaluate the effect of sanguiin H-6 and lambertianin C fractionated from cloudberry seeds, on the MRSA growth, and as treatment of a MRSA biofilm development in different growth media in vitro and in vivo by using a murine wound infection model where sanguiin H-6 and lambertianin C were used to prevent the MRSA infection. Sanguiin H-6 and lambertianin C inhibited the in vitro biofilm development and growth of MRSA. Furthermore, sanguiin H-6 showed significant anti-MRSA effect in the in vivo wound model. Our study shows the possible use of sanguiin H-6 as a preventive measure in surgical sites to avoid postoperative infections, whilst lambertianin C showed no anti-MRSA activity.

Item Description

10.3390/antibiotics10121481
2079-6382