Lack of association between polymorphisms of the <it>IL18R1 </it>and <it>IL18RAP </it>genes and cardiovascular risk: the MORGAM Project

• Main Authors: Nicaud Viviane (Author), Cambien François (Author), Kuulasmaa Kari (Author), Salomaa Veikko (Author), DeSuremain Maylis (Author), Alanne Mervi (Author), Proust Carole (Author), Grisoni Marie-Lise (Author), Wiklund Per-Gunnar (Author), Virtamo Jarmo (Author), Kee Frank (Author), Tiret Laurence (Author), Evans Alun (Author), Tregouet David-Alexandre (Author)
• Format: Book
• Published: BMC, 2009-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

<p>Abstract</p> <p>Background</p> <p>Interleukin-18 is a pro-inflammatory cytokine suspected to be associated with atherosclerosis and its complications. We had previously shown that one single nucleotide polymorphism (SNP) of the <it>IL18 </it>gene was associated with cardiovascular disease (CVD) through an interaction with smoking. As a further step for elucidating the contribution of the IL-18 pathway to the etiology of CVD, we here investigated the association between the genetic variability of two IL-18 receptor genes, <it>IL18R1 </it>and <it>IL18RAP</it>, with the risk of developing CVD.</p> <p>Methods</p> <p>Eleven tagging SNPs, 5 in <it>IL18R1 </it>and 6 in <it>IL18RAP</it>, characterizing the haplotypic variability of the corresponding genes; were genotyped in 5 European prospective CVD cohorts including 1416 cases and 1772 non-cases, as part of the MORGAM project. Both single-locus and haplotypes analyses were carried out to investigate the association of these SNPs with CVD.</p> <p>Results</p> <p>We did not find any significant differences in allele, genotype and haplotype frequencies between cases and non-cases for either of the two genes. Moreover, the search for interactions between SNPs located in different genes, including 5 <it>IL18 </it>SNPs previously studied in the MORGAM project, and between SNPs and environmental factors remained unfruitful.</p> <p>Conclusion</p> <p>Our analysis suggests that the variability of <it>IL18R1 </it>and <it>IL18RAP </it>genes are unlikely to contribute to modulate the risk of CVD.</p>

Item Description

10.1186/1471-2350-10-44
1471-2350