Investigation of the Transport Pathways Associated with Enhanced Brain Delivery of Peptide Drugs by Intranasal Coadministration with Penetratin

• Main Authors: Noriyasu Kamei (Author), Susumu Suwabe (Author), Kenji Arime (Author), Hidemi Bando (Author), Kaho Murata (Author), Maika Yamaguchi (Author), Natsuki Yokoyama (Author), Erina Tanaka (Author), Ayaka Hashimoto (Author), Takanori Kanazawa (Author), Yukio Ago (Author), Mariko Takeda-Morishita (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously found that coadministering peptides and proteins with the cell-penetrating peptide L-penetratin intranasally significantly increased transport to the brain and enhanced pharmacological effects. The present study aimed to clarify the mechanisms of nose-to-brain drug delivery enhancement...